8
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6228 | Irinotecan | CPT-11,Topotecin,(+)-Irinotecan | Topoisomerase , Autophagy |
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting... | |||
T0486L | Irinotecan Hydrochloride | Camptothecin 11 hydrochloride,CPT-11 hydrochloride | Topoisomerase , Autophagy |
Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptoth... | |||
T0486 | Irinotecan hydrochloride trihydrate | Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate | Topoisomerase , Autophagy |
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1. | |||
T19553 | RPR132595A | NPC | Others |
RPR132595A is an active CPT-11 metabolite, it is generated by cytochrome P-450 3A4 (CYP3A4). | |||
T78069 | RPR132595A hydrochloride | NPC hydrochloride | Drug Metabolite |
RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via urinary excretion [1]. | |||
T38474 | CL2-MMT-SN38 | CL2-MMT-SN38 | |
CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor. | |||
T70380 | ZBH-1205 | ||
ZBH-1205 is a novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than cpt-11 and sn38 at inhibiting topoismerase-1 | |||
T78711 | A011 | ATM/ATR | |
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumo... |